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Wiki Wiki Summary
Equity (finance) In finance, equity is ownership of assets that may have debts or other liabilities attached to them. Equity is measured for accounting purposes by subtracting liabilities from the value of the assets.
Technology Technology is the result of accumulated knowledge and application of skills, methods, and processes used in industrial production and scientific research. Technology is embedded in the operation of all machines, with or without detailed knowledge of their function, for the intended purpose of an organization.
Educational technology Educational technology (commonly abbreviated as edutech, or edtech) is the combined use of computer hardware, software, and educational theory and practice to facilitate learning. When referred to with its abbreviation, edtech, it is often referring to the industry of companies that create educational technology.In addition to practical educational experience, educational technology is based on theoretical knowledge from various disciplines such as communication, education, psychology, sociology, artificial intelligence, and computer science.
Financial technology Financial technology (abbreviated fintech or FinTech) is the technology and innovation that aims to compete with traditional financial methods in the delivery of financial services. It is an emerging industry that uses technology to improve activities in finance.
Language technology Language technology, often called human language technology (HLT), studies methods of how computer programs or electronic devices can analyze, produce, modify or respond to human texts and speech. Working with language technology often requires broad knowledge not only about linguistics but also about computer science.
Space technology Space technology is technology for use in outer space, in travel (astronautics) or other activities beyond Earth's atmosphere, for purposes such as spaceflight, space exploration, and Earth observation. Space technology includes space vehicles such as spacecraft, satellites, space stations and orbital launch vehicles; deep-space communication; in-space propulsion; and a wide variety of other technologies including support infrastructure equipment, and procedures.
Information technology consulting In management, information technology consulting (also called IT consulting, computer consultancy, business and technology services, computing consultancy, technology consulting, and IT advisory) is a field of activity which focuses on advising organizations on how best to use information technology (IT) in achieving their business objectives.\nOnce a business owner defines the needs to take a business to the next level, a decision maker will define a scope, cost and a time frame of the project.
Bachelor of Technology A Bachelor of Technology (Latin Baccalaureus Technologiae, commonly abbreviated as B.Tech. or BTech; with honours as B.Tech.
Public company A public company, publicly traded company, publicly held company, publicly listed company, or public limited company is a company whose ownership is organized via shares of stock which are intended to be freely traded on a stock exchange or in over-the-counter markets. A public (publicly traded) company can be listed on a stock exchange (listed company), which facilitates the trade of shares, or not (unlisted public company).
Renewable energy commercialization Renewable energy commercialization involves the deployment of three generations of renewable energy technologies dating back more than 100 years. First-generation technologies, which are already mature and economically competitive, include biomass, hydroelectricity, geothermal power and heat.
Commercial use of space Commercial use of space is the provision of goods or services of commercial value by using equipment sent into Earth orbit or outer space. This phenomenon – aka Space Economy (or New Space Economy) – is accelerating cross-sector innovation processes combining the most advanced space and digital technologies to develop a broad portfolio of space-based services.
Sustainable development Sustainable development is an organizing principle for meeting human development goals while also sustaining the ability of natural systems to provide the natural resources and ecosystem services on which the economy and society depend. The desired result is a state of society where living conditions and resources are used to continue to meet human needs without undermining the integrity and stability of the natural system.
Arrested Development Arrested Development is an American television sitcom created by Mitchell Hurwitz, which originally aired on Fox for three seasons from 2003 to 2006, followed by a two-season revival on Netflix from 2013 to 2019. The show follows the Bluths, a formerly wealthy dysfunctional family.
Development/For! Development/For! (Latvian: Attīstībai/Par!, AP!) is a liberal political alliance in Latvia.
Research and development Research and development (R&D or R+D), known in Europe as research and technological development (RTD), is the set of innovative activities undertaken by corporations or governments in developing new services or products, and improving existing ones. Research and development constitutes the first stage of development of a potential new service or the production process.
Management development Management development is the process by which managers learn and improve their management skills.\n\n\n== Background ==\nIn organisational development, management effectiveness is recognized as a determinant of organisational success.
Commercialization Commercialization or commercialisation is the process of introducing a new product or production method into commerce—making it available on the market. The term often connotes especially entry into the mass market (as opposed to entry into earlier niche markets), but it also includes a move from the laboratory into (even limited) commerce.
The Managed Heart The Managed Heart: Commercialization of Human Feeling, by Arlie Russell Hochschild, was first published in 1983. A 20th Anniversary edition with a new afterword added by the author was published in 2003.
Commercial software Commercial software, or seldom payware, is a computer software that is produced for sale or that serves commercial purposes. Commercial software can be proprietary software or free and open-source software.
Commercialization of love The notion of commercialization of love, that is not to be confused with prostitution (the commercialization of sexual activity), involves the definitions of romantic love and consumerism.\n\n\n== Sociological development ==\nThe commercialization of love is the ongoing process of infiltration of commercial and economical stimuli in the daily life of lovers and the association of monetary and non-monetary symbols and commodities in the love relationships.
Bioprospecting Bioprospecting (also known as biodiversity prospecting) is the exploration of natural sources for small molecules, macromolecules and biochemical and genetic information that could be developed into commercially valuable products for the agricultural, aquaculture, bioremediation, cosmetics, nanotechnology, or pharmaceutical industries. In the pharmaceutical industry, for example, almost one third of all small-molecule drugs approved by the U.S. Food and Drug Administration (FDA) between 1981 and 2014 were either natural products or compounds derived from natural products.Terrestrial plants, fungi and actinobacteria have been the focus of many past bioprospecting programs, but interest is growing in less explored ecosystems (e.g.
Stock market A stock market, equity market, or share market is the aggregation of buyers and sellers of stocks (also called shares), which represent ownership claims on businesses; these may include securities listed on a public stock exchange, as well as stock that is only traded privately, such as shares of private companies which are sold to investors through equity crowdfunding platforms. Investment is usually made with an investment strategy in mind.
Consolidation (business) In business, consolidation or amalgamation is the merger and acquisition of many smaller companies into a few much larger ones. In the context of financial accounting, consolidation refers to the aggregation of financial statements of a group company as consolidated financial statements.
Common stock dividend A common stock dividend is the dividend paid to common stock owners from the profits of the company. Like other dividends, the payout is in the form of either cash or stock.
Matthiola incana Matthiola incana is a species of flowering plant in the cabbage family Brassicaceae. Common names include Brompton stock, common stock, hoary stock, ten-week stock, and gilly-flower.
New York Stock Exchange The New York Stock Exchange (NYSE, nicknamed "The Big Board") is an American stock exchange in the Financial District of Lower Manhattan in New York City. It is by far the world's largest stock exchange by market capitalization of its listed companies at US$30.1 trillion as of February 2018.
Convertible bond In finance, a convertible bond or convertible note or convertible debt (or a convertible debenture if it has a maturity of greater than 10 years) is a type of bond that the holder can convert into a specified number of shares of common stock in the issuing company or cash of equal value. It is a hybrid security with debt- and equity-like features.
Shareholders' agreement A shareholders' agreement (sometimes referred to in the U.S. as a stockholders' agreement) (SHA) is an agreement amongst the shareholders or members of a company. In practical effect, it is analogous to a partnership agreement.
Shareholder A shareholder (in the United States often referred to as stockholder) of a corporation is an individual or legal entity (such as another corporation, a body politic, a trust or partnership) that is registered by the corporation as the legal owner of shares of the share capital of a public or private corporation. Shareholders may be referred to as members of a corporation.
Stockholder of record Stockholder of record is the name of an individual or entity shareholder that an issuer carries in its shareholder register as the registered holder (not necessarily the beneficial owner) of the issuer's securities. Dividends and other distributions are paid only to shareholders of record.
Jessica Stockholder Jessica Stockholder (born 1959) is a Canadian-American artist known for site-specific installation works and sculptures that are often described as "paintings in space." She came to prominence in the early 1990s with monumental works that challenged boundaries between artwork and display environment as well as between pictorial and physical experience. Her art often presents a "barrage" of bold colors, textures and everyday objects, incorporating floors, walls and ceilings and sometimes spilling out of exhibition sites.
Derivative suit A shareholder derivative suit is a lawsuit brought by a shareholder on behalf of a corporation against a third party. Often, the third party is an insider of the corporation, such as an executive officer or director.
Friedman doctrine The Friedman doctrine, also called shareholder theory or stockholder theory, is a normative theory of business ethics advanced by economist Milton Friedman which holds that the social responsibility of business is to increase its profits. This shareholder primacy approach views shareholders as the economic engine of the organization and the only group to which the firm is socially responsible.
Risk Factors
SENESCO TECHNOLOGIES INC Item 1A Risk Factors
16 ______________________________________________________________________ We have a limited operating history and have incurred substantial losses and expect future losses
We are a development stage biotechnology company with a limited operating history and limited assets and capital
We have incurred losses each year since inception and have an accumulated deficit of dlra22cmam369cmam843 at June 30, 2006
We have generated minimal revenues by licensing our technology for certain crops to companies willing to share in our development costs
However, our technology may not be ready for widespread commercialization for several years
We expect to continue to incur losses for the next several years because we anticipate that our expenditures on research and development, commercialization and administrative activities will significantly exceed our revenues during that period
In addition, we cannot assure you that we will be able to sell our New Jersey state net operating losses for any specific fiscal year
We cannot predict when, if ever, we will become profitable
We depend on a single principal technology and, if our technology is not commercially successful, we will have no alternative source of revenue
Our primary business is the development and commercial exploitation of technology to identify, isolate, characterize and silence genes which control the death of cells in humans and plants
Our future revenue and profitability critically depend upon our ability to successfully develop apoptosis and senescence gene technology and later license or market such technology
We have conducted experiments on certain crops with favorable results and have conducted certain preliminary cell-line and animal experiments, which have provided us with data upon which we have designed additional research programs
However, we cannot give any assurance that our technology will be commercially successful or economically viable for any crops or human health applications
In addition, no assurance can be given that adverse consequences might not result from the use of our technology such as the development of negative effects on humans or plants or reduced benefits in terms of crop yield or protection
Our failure to obtain market acceptance of our technology or to successfully commercialize such technology or develop a commercially viable product would have a material adverse effect on our business
We outsource all of our research and development activities and, if we are unsuccessful in maintaining our alliances with these third parties, our research and development efforts may be delayed or curtailed
We rely on third parties to perform all of our research and development activities
Our primary research and development efforts take place at the University of Waterloo in Ontario, Canada, where our technology was discovered, the University of Colorado, Mayo Clinic, the University of Virginia, the University of Pittsburgh, and with our commercial partners
At this time, we do not have the internal capabilities to perform our research and development activities
Accordingly, the failure of third-party research partners, such as the University of Waterloo, to perform under agreements entered into with us, or our failure to renew important research agreements with these third parties, may delay or curtail our research and development efforts
17 ______________________________________________________________________ We have significant future capital needs and may be unable to raise capital when needed, which could force us to delay or reduce our research and development efforts
As of June 30, 2006, we had cash and highly-liquid investments valued at dlra1cmam168cmam473 and working capital of dlra858cmam811
In October 2006, we received aggregate net proceeds of dlra2cmam050cmam000 from a private placement of our equity securities
Using our available reserves as of June 30, 2006, and the net proceeds from the private equity financing, we believe that we can operate according to our current business plan at least through June 30, 2007
To date, we have generated minimal revenues and anticipate that our operating costs will exceed any revenues generated over the next several years
Therefore, we will be required to raise additional capital in the future in order to operate according to our current business plan, and this funding may not be available on favorable terms, if at all
If we are unable to raise additional funds, we will need to do one or more of the following: · delay, scale back or eliminate some or all of our research and development programs; · license third parties to develop and commercialize our technology that we would otherwise seek to develop and commercialize ourselves; · seek strategic alliances or business combinations, or attempt to sell our company; or · cease operations
In addition, in connection with any funding, if we need to issue more equity securities than our certificate of incorporation currently authorizes, or more than 20prca of the shares of our common stock outstanding, we may need stockholder approval
If stockholder approval is not obtained or if adequate funds are not available, we may be required to curtail operations significantly or to obtain funds through arrangements with collaborative partners or others that may require us to relinquish rights to certain of our technologies, product candidates, products or potential markets
Investors may experience dilution in their investment from future offerings of our common stock
For example, if we raise additional capital by issuing equity securities, such an issuance would reduce the percentage ownership of existing stockholders
In addition, assuming the exercise of all options and warrants outstanding, as of June 30, 2006, we had 6cmam226cmam021 shares of common stock authorized but unissued, which may be issued from time to time by our board of directors without stockholder approval
In connection with our private placement of equity securities, in October 2006, we issued an aggregate of an additional 1cmam986cmam306 shares of common stock and warrants to purchase 1cmam132cmam194 shares of common stock
Therefore assuming the exercise of all options and warrants granted as of October 11, 2006, we had 3cmam107cmam521 shares of common stock authorized but unissued, which may be issued from time to time by our board of directors without stockholder approval
Furthermore, we may need to issue securities that have rights, preferences and privileges senior to our common stock
Since our inception, we have financed all of our operations through private equity financings
Our future capital requirements depend on numerous factors, including: · the scope of our research and development; · our ability to attract business partners willing to share in our development costs; · our ability to successfully commercialize our technology; · competing technological and market developments; · our ability to enter into collaborative arrangements for the development, regulatory approval and commercialization of other products; and · the cost of filing, prosecuting, defending and enforcing patent claims and other intellectual property rights
18 ______________________________________________________________________ Our business depends upon our patents and proprietary rights and the enforcement of these rights
Our failure to obtain and maintain patent protection may increase competition and reduce demand for our technology
As a result of the substantial length of time and expense associated with developing products and bringing them to the marketplace in the biotechnology and agricultural industries, obtaining and maintaining patent and trade secret protection for technologies, products and processes is of vital importance
Our success will depend in part on several factors, including, without limitation: · our ability to obtain patent protection for our technologies and processes; · our ability to preserve our trade secrets; and · our ability to operate without infringing the proprietary rights of other parties both in the United States and in foreign countries
We have been issued ten patents by the US Patent and Trademark Office, or PTO, and eight patents from foreign countries
We have also filed numerous patent applications for our technology in the United States and in several foreign countries, which technology is vital to our primary business, as well as several Continuations in Part on these patent applications
Our success depends in part upon the grant of patents from our pending patent applications
Although we believe that our technology is unique and will not violate or infringe upon the proprietary rights of any third party, we cannot assure you that these claims will not be made or if made, could be successfully defended against
If we do not obtain and maintain patent protection, we may face increased competition in the United States and internationally, which would have a material adverse effect on our business
Since patent applications in the United States are maintained in secrecy until patents are issued, and since publication of discoveries in the scientific and patent literature tend to lag behind actual discoveries by several months, we cannot be certain that we were the first creator of the inventions covered by our pending patent applications or that we were the first to file patent applications for these inventions
In addition, among other things, we cannot assure you that: · our patent applications will result in the issuance of patents; · any patents issued or licensed to us will be free from challenge and that if challenged, would be held to be valid; · any patents issued or licensed to us will provide commercially significant protection for our technology, products and processes; · other companies will not independently develop substantially equivalent proprietary information which is not covered by our patent rights; · other companies will not obtain access to our know-how; · other companies will not be granted patents that may prevent the commercialization of our technology; or · we will not require licensing and the payment of significant fees or royalties to third parties for the use of their intellectual property in order to enable us to conduct our business
19 ______________________________________________________________________ Our competitors may allege that we are infringing upon their intellectual property rights, forcing us to incur substantial costs and expenses in resulting litigation, the outcome of which would be uncertain
Patent law is still evolving relative to the scope and enforceability of claims in the fields in which we operate
We are like most biotechnology companies in that our patent protection is highly uncertain and involves complex legal and technical questions for which legal principles are not yet firmly established
In addition, if issued, our patents may not contain claims sufficiently broad to protect us against third parties with similar technologies or products, or provide us with any competitive advantage
The PTO and the courts have not established a consistent policy regarding the breadth of claims allowed in biotechnology patents
The allowance of broader claims may increase the incidence and cost of patent interference proceedings and the risk of infringement litigation
On the other hand, the allowance of narrower claims may limit the value of our proprietary rights
The laws of some foreign countries do not protect proprietary rights to the same extent as the laws of the United States, and many companies have encountered significant problems and costs in protecting their proprietary rights in these foreign countries
We could become involved in infringement actions to enforce and/or protect our patents
Regardless of the outcome, patent litigation is expensive and time consuming and would distract our management from other activities
Some of our competitors may be able to sustain the costs of complex patent litigation more effectively than we could because they have substantially greater resources
Uncertainties resulting from the initiation and continuation of any patent litigation could limit our ability to continue our operations
If our technology infringes the intellectual property of our competitors or other third parties, we may be required to pay license fees or damages
If any relevant claims of third-party patents that are adverse to us are upheld as valid and enforceable, we could be prevented from commercializing our technology or could be required to obtain licenses from the owners of such patents
We cannot assure you that such licenses would be available or, if available, would be on acceptable terms
Some licenses may be non-exclusive and, therefore, our competitors may have access to the same technology licensed to us
In addition, if any parties successfully claim that the creation or use of our technology infringes upon their intellectual property rights, we may be forced to pay damages, including treble damages
Our security measures may not adequately protect our unpatented technology and, if we are unable to protect the confidentiality of our proprietary information and know-how, the value of our technology may be adversely affected
Our success depends upon know-how, unpatentable trade secrets, and the skills, knowledge and experience of our scientific and technical personnel
As a result, we require all employees to agree to a confidentiality provision that prohibits the disclosure of confidential information to anyone outside of our company, during the term of employment and thereafter
We also require all employees to disclose and assign to us the rights to their ideas, developments, discoveries and inventions
We also attempt to enter into similar agreements with our consultants, advisors and research collaborators
We cannot assure you that adequate protection for our trade secrets, know-how or other proprietary information against unauthorized use or disclosure will be available
20 ______________________________________________________________________ We occasionally provide information to research collaborators in academic institutions and request the collaborators to conduct certain tests
We cannot assure you that the academic institutions will not assert intellectual property rights in the results of the tests conducted by the research collaborators, or that the academic institutions will grant licenses under such intellectual property rights to us on acceptable terms, if at all
If the assertion of intellectual property rights by an academic institution is substantiated, and the academic institution does not grant intellectual property rights to us, these events could limit our ability to commercialize our technology
As we evolve from a company primarily involved in the research and development of our technology into one that is also involved in the commercialization of our technology, we may have difficulty managing our growth and expanding our operations
As our business grows, we may need to add employees and enhance our management, systems and procedures
We will need to successfully integrate our internal operations with the operations of our marketing partners, manufacturers, distributors and suppliers to produce and market commercially viable products
We may also need to manage additional relationships with various collaborative partners, suppliers and other organizations
Although we do not presently conduct research and development activities in-house, we may undertake those activities in the future
Expanding our business will place a significant burden on our management and operations
We may not be able to implement improvements to our management information and control systems in an efficient and timely manner and we may discover deficiencies in our existing systems and controls
Our failure to effectively respond to changes may make it difficult for us to manage our growth and expand our operations
We have no marketing or sales history and depend on third-party marketing partners
Any failure of these parties to perform would delay or limit our commercialization efforts
We have no history of marketing, distributing or selling biotechnology products and we are relying on our ability to successfully establish marketing partners or other arrangements with third parties to market, distribute and sell a commercially viable product both here and abroad
Our business plan also envisions creating strategic alliances to access needed commercialization and marketing expertise
We may not be able to attract qualified sub-licensees, distributors or marketing partners, and even if qualified, these marketing partners may not be able to successfully market agricultural products or human health applications developed with our technology
If we fail to successfully establish distribution channels, or if our marketing partners fail to provide adequate levels of sales, our commercialization efforts will be delayed or limited and we will not be able to generate revenue
We will depend on joint ventures and strategic alliances to develop and market our technology and, if these arrangements are not successful, our technology may not be developed and the expenses to commercialize our technology will increase
In its current state of development, our technology is not ready to be marketed to consumers
We intend to follow a multi-faceted commercialization strategy that involves the licensing of our technology to business partners for the purpose of further technological development, marketing and distribution
We are seeking business partners who will share the burden of our development costs while our technology is still being developed, and who will pay us royalties when they market and distribute products incorporating our technology upon 21 ______________________________________________________________________ commercialization
The establishment of joint ventures and strategic alliances may create future competitors, especially in certain regions abroad where we do not pursue patent protection
If we fail to establish beneficial business partners and strategic alliances, our growth will suffer and the continued development of our technology may be harmed
Competition in the agricultural and human health biotechnology industries is intense and technology is changing rapidly
If our competitors market their technology faster than we do, we may not be able to generate revenues from the commercialization of our technology
Many agricultural and human health biotechnology companies are engaged in research and development activities relating to senescence and apoptosis
The market for plant protection and yield enhancement products is intensely competitive, rapidly changing and undergoing consolidation
We may be unable to compete successfully against our current and future competitors, which may result in price reductions, reduced margins and the inability to achieve market acceptance for products containing our technology
Our competitors in the field of plant senescence gene technology are companies that develop and produce transgenic plants and include major international agricultural companies, specialized biotechnology companies, research and academic institutions and, potentially, our joint venture and strategic alliance partners
Some of our competitors that are involved in apoptosis research include: Amgen; Centocor; Genzyme; OSI Pharmaceuticals, Inc
; and Vertex Pharmaceuticals, Inc
Many of these competitors have substantially greater financial, marketing, sales, distribution and technical resources than us and have more experience in research and development, clinical trials, regulatory matters, manufacturing and marketing
We anticipate increased competition in the future as new companies enter the market and new technologies become available
Our technology may be rendered obsolete or uneconomical by technological advances or entirely different approaches developed by one or more of our competitors, which will prevent or limit our ability to generate revenues from the commercialization of our technology
Our business is subject to various government regulations and, if we are unable to obtain regulatory approval, we may not be able to continue our operations
At present, the US federal government regulation of biotechnology is divided among three agencies: · the USDA regulates the import, field testing and interstate movement of specific types of genetic engineering that may be used in the creation of transgenic plants; · the EPA regulates activity related to the invention of plant pesticides and herbicides, which may include certain kinds of transgenic plants; and · the FDA regulates foods derived from new plant varieties
The FDA requires that transgenic plants meet the same standards for safety that are required for all other plants and foods in general
Except in the case of additives that significantly alter a food’s structure, the FDA does not require any additional standards or specific approval for genetically engineered foods, but expects transgenic plant developers to consult the FDA before introducing a new food into the marketplace
22 ______________________________________________________________________ Use of our technology, if developed for human health applications, will also be subject to FDA regulation
The FDA must approve any drug or biologic product before it can be marketed in the United States
In addition, prior to being sold outside of the US, any products resulting from the application of our human health technology must be approved by the regulatory agencies of foreign governments
Prior to filing a new drug application or biologics license application with the FDA, we would have to perform extensive clinical trials, and prior to beginning any clinical trial, we need to perform extensive preclinical testing which could take several years and may require substantial expenditures
We believe that our current activities, which to date have been confined to research and development efforts, do not require licensing or approval by any governmental regulatory agency
However, federal, state and foreign regulations relating to crop protection products and human health applications developed through biotechnology are subject to public concerns and political circumstances, and, as a result, regulations have changed and may change substantially in the future
Accordingly, we may become subject to governmental regulations or approvals or become subject to licensing requirements in connection with our research and development efforts
We may also be required to obtain such licensing or approval from the governmental regulatory agencies described above, or from state agencies, prior to the commercialization of our genetically transformed plants and human health technology
In addition, our marketing partners who utilize our technology or sell products grown with our technology may be subject to government regulations
If unfavorable governmental regulations are imposed on our technology or if we fail to obtain licenses or approvals in a timely manner, we may not be able to continue our operations
Preclinical studies and clinical trials of our human health applications may be unsuccessful, which could delay or prevent regulatory approval
Preclinical studies may reveal that our human health technology is ineffective or harmful, and/or clinical trials may be unsuccessful in demonstrating efficacy and safety of our human health technology, which would significantly limit the possibility of obtaining regulatory approval for any drug or biologic product manufactured with our technology
The FDA requires submission of extensive preclinical, clinical and manufacturing data to assess the efficacy and safety of potential products
Furthermore, the success of preliminary studies does not ensure commercial success, and later-stage clinical trials may fail to confirm the results of the preliminary studies
Even if we receive regulatory approval, consumers may not accept products containing our technology, which will prevent us from being profitable since we have no other source of revenue
We cannot guarantee that consumers will accept products containing our technology
Recently, there has been consumer concern and consumer advocate activism with respect to genetically engineered consumer products
The adverse consequences from heightened consumer concern in this regard could affect the markets for products developed with our technology and could also result in increased government regulation in response to that concern
If the public or potential customers perceive our technology to be genetic modification or genetic engineering, agricultural products grown with our technology may not gain market acceptance
23 ______________________________________________________________________ We depend on our key personnel and, if we are not able to attract and retain qualified scientific and business personnel, we may not be able to grow our business or develop and commercialize our technology
We are highly dependent on our scientific advisors, consultants and third-party research partners
Our success will also depend in part on the continued service of our key employees and our ability to identify, hire and retain additional qualified personnel in an intensely competitive market
Although we have employment agreements with all of our key employees and a research agreement with Dr
Thompson, these agreements may be terminated upon short or no notice
We do not maintain key person life insurance on any member of management
The failure to attract and retain key personnel could limit our growth and hinder our research and development efforts
Certain provisions of our charter, by-laws and Delaware law could make a takeover difficult
Certain provisions of our certificate of incorporation and by-laws could make it more difficult for a third party to acquire control of us, even if the change in control would be beneficial to stockholders
Our certificate of incorporation authorizes our board of directors to issue, without stockholder approval, except as may be required by the rules of the American Stock Exchange, 5cmam000cmam000 shares of preferred stock with voting, conversion and other rights and preferences that could adversely affect the voting power or other rights of the holders of our common stock
Similarly, our by-laws do not restrict our board of directors from issuing preferred stock without stockholder approval
In addition, we are subject to the Business Combination Act of the Delaware General Corporation Law which, subject to certain exceptions, restricts certain transactions and business combinations between a corporation and a stockholder owning 15prca or more of the corporation’s outstanding voting stock for a period of three years from the date such stockholder becomes a 15prca owner
These provisions may have the effect of delaying or preventing a change of control of us without action by our stockholders and, therefore, could adversely affect the value of our common stock
Furthermore, in the event of our merger or consolidation with or into another corporation, or the sale of all or substantially all of our assets in which the successor corporation does not assume outstanding options or issue equivalent options, our board of directors is required to provide accelerated vesting of outstanding options
Increasing political and social turmoil, such as terrorist and military actions, increase the difficulty for us and our strategic partners to forecast accurately and plan future business activities
Recent political and social turmoil, including the conflict in Iraq and the current crisis in the Middle East, can be expected to put further pressure on economic conditions in the United States and worldwide
These political, social and economic conditions may make it difficult for us to plan future business activities
Specifically, if the current situation in Israel continues to escalate, our joint venture with Rahan Meristem Ltd
could be adversely affected
24 ______________________________________________________________________ Risks Related to Our Common Stock Our management and other affiliates have significant control of our common stock and could significantly influence our actions in a manner that conflicts with our interests and the interests of other stockholders
As of June 30, 2006, our executive officers, directors and affiliated entities together beneficially own approximately 41dtta4prca of the outstanding shares of our common stock, assuming the exercise of options and warrants which are currently exercisable or will become exercisable within 60 days of June 30, 2006, held by these stockholders
As of October 11, 2006, upon the closing of our private placement of equity securities, our executive officers, directors, and affiliated entities together beneficially own approximately 37dtta2prca of the Outstanding shares of our common stock, assuming the exercise of options and warrants which are currently exercisable or will become exercisable within 60 days of October 11, 2006, held by these stockholders
As a result, these stockholders, acting together, will be able to exercise significant influence over matters requiring approval by our stockholders, including the election of directors, and may not always act in the best interests of other stockholders
Such a concentration of ownership may have the effect of delaying or preventing a change in control of us, including transactions in which our stockholders might otherwise receive a premium for their shares over then current market prices
Our stockholders may experience substantial dilution as a result of the exercise of outstanding options and warrants to purchase our common stock
As of June 30, 2006, we have granted options outside of our stock option plan to purchase 10cmam000 shares of our common stock and outstanding warrants to purchase 5cmam860cmam091 shares of our common stock
In addition, as of June 30, 2006, we have reserved 3cmam000cmam000 shares of our common stock for issuance upon the exercise of options granted pursuant to our stock option plan, 2cmam516cmam500 of which have been granted, 90cmam000 of which have been exercised, 2cmam426cmam500 of which are outstanding, and 483cmam500 of which may be granted in the future
As of October 11, 2006, upon the closing of our private placement of equity securities, we have outstanding warrants to purchase 6cmam982cmam285 shares of our common stock
The exercise of these options and warrants will result in dilution to our existing stockholders and could have a material adverse effect on our stock price
A significant portion of our total outstanding shares of common stock may be sold in the market in the near future, which could cause the market price of our common stock to drop significantly
As of June 30, 2006, we had 15cmam477cmam388 shares of our common stock issued and outstanding, of which approximately 1cmam595cmam651 shares are registered pursuant to a registration statement on Form S-3, which was declared effective on June 17, 2005, and the remainder of which are either eligible to be sold under SEC Rule 144 or are in the public float
In addition, we have registered 965cmam380 shares of our Common Stock underlying warrants previously issued on the Form S-3 registration statement that was declared effective on June 17, 2005, and we registered 3cmam000cmam000 shares of our common stock underlying options granted or to be granted under our stock option plan
As of October 11, 2006, upon the closing of our private placement of equity securities, we had 17cmam473cmam694 shares of our common stock issued and outstanding
Consequently, sales of substantial amounts of our common stock in the public market, or the perception that such sales could occur, may have a material adverse effect on our stock price
Our common stock has a limited trading market, which could limit your ability to resell your shares of common stock at or above your purchase price
Our common stock is quoted on the American Stock Exchange and currently has a limited trading market
The American Stock Exchange requires us to meet minimum financial requirements in order to maintain our listing
Currently, we believe that we meet the continued listing requirements of the American Stock Exchange
We cannot assure you that an active trading market will develop or, if developed, will 25 ______________________________________________________________________ be maintained
As a result, our stockholders may find it difficult to dispose of shares of our common stock and, as a result, may suffer a loss of all or a substantial portion of their investment
If our common stock is delisted from the American Stock Exchange, we may not be able to list on any other stock exchange, and our common stock may be subject to the “penny stockregulations which may affect the ability of our stockholders to sell their shares
The American Stock Exchange requires us to meet minimum financial requirements in order to maintain our listing
Currently, we believe that we meet the continued listing requirements of the American Stock Exchange
If we do not continue to meet the continued listing requirements, we could be delisted
If we are delisted from the American Stock Exchange, our common stock likely will become a “penny stock
” In general, regulations of the SEC define a “penny stock” to be an equity security that is not listed on a national securities exchange or the NASDAQ Stock Market and that has a market price of less than dlra5dtta00 per share or with an exercise price of less than dlra5dtta00 per share, subject to certain exceptions
If our common stock becomes a penny stock, additional sales practice requirements would be imposed on broker-dealers that sell such securities to persons other than certain qualified investors
For transactions involving a penny stock, unless exempt, a broker-dealer must make a special suitability determination for the purchaser and receive the purchaser’s written consent to the transaction prior to the sale
In addition, the rules on penny stocks require delivery, prior to and after any penny stock transaction, of disclosures required by the SEC If our common stock were subject to the rules on penny stocks, the market liquidity for our common stock could be severely and adversely affected
Accordingly, the ability of holders of our common stock to sell their shares in the secondary market may also be adversely affected
The market price of our common stock may fluctuate and may drop below the price you paid
We cannot assure you that you will be able to resell the shares of our common stock at or above your purchase price
The market price of our common stock may fluctuate significantly in response to a number of factors, some of which are beyond our control
These factors include: · quarterly variations in operating results; · the progress or perceived progress of our research and development efforts; · changes in accounting treatments or principles; · announcements by us or our competitors of new technology, product and service offerings, significant contracts, acquisitions or strategic relationships; · additions or departures of key personnel; · future offerings or resales of our common stock or other securities; · stock market price and volume fluctuations of publicly-traded companies in general and development companies in particular; and · general political, economic and market conditions
Because we do not intend to pay, and have not paid, any cash dividends on our shares of common stock, our stockholders will not be able to receive a return on their shares unless the value of our common stock appreciates and they sell their shares
We have never paid or declared any cash dividends on our common stock and we intend to retain any future earnings to finance the development and expansion of our business
We do not anticipate paying any cash dividends on our common stock in the foreseeable future
Therefore, our stockholders will not be able to receive a return on their investment unless the value of our common stock appreciates and they sell their shares