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You've Got to Be Carefully Taught "You've Got to Be Carefully Taught" (sometimes "You've Got to Be Taught" or "Carefully Taught") is a show tune from the 1949 Rodgers and Hammerstein musical South Pacific.\nSouth Pacific received scrutiny for its commentary regarding relationships between different races and ethnic groups.
Uncertainty parameter The uncertainty parameter U is a parameter introduced by the Minor Planet Center (MPC) to quantify concisely the uncertainty of a perturbed orbital solution for a minor planet. The parameter is a logarithmic scale from 0 to 9 that measures the anticipated longitudinal uncertainty in the minor planet's mean anomaly after 10 years.
Cone of Uncertainty In project management, the Cone of Uncertainty describes the evolution of the amount of best case uncertainty during a project. At the beginning of a project, comparatively little is known about the product or work results, and so estimates are subject to large uncertainty.
Cirsium Cirsium is a genus of perennial and biennial flowering plants in the Asteraceae, one of several genera known commonly as thistles. They are more precisely known as plume thistles.
Monopolistic competition Monopolistic competition is a type of imperfect competition such that there are many producers competing against each other, but selling products that are differentiated from one another (e.g. by branding or quality) and hence are not perfect substitutes.
IP address An Internet Protocol address (IP address) is a numerical label such as 192.0.2.1 that is connected to a computer network that uses the Internet Protocol for communication. An IP address serves two main functions: network interface identification and location addressing.
Seychelles Seychelles ( (listen), ; French: [sɛʃɛl] or [seʃɛl]), officially the Republic of Seychelles (French: République des Seychelles; Creole: La Repiblik Sesel), is an archipelagic island country consisting of 115 islands in the Indian Ocean at the eastern edge of the Somali Sea. Its capital and largest city, Victoria, is 1,500 kilometres (800 nautical miles) east of mainland Africa.
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Preclinical development In drug development, preclinical development, also termed preclinical studies or nonclinical studies, is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals.\nThe main goals of preclinical studies are to determine a starting, safe dose for first-in-human study and assess potential toxicity of the product, which typically include new medical devices, prescription drugs, and diagnostics.
Medical laboratory scientist A medical laboratory scientist (MLS) or clinical laboratory scientist (CLS) or medical technologist (MT) performs diagnostic testing of blood and body fluids in clinical laboratories. The scope of a medical laboratory scientist's work begins with the receipt of patient or client specimens and terminates with the delivery of test results to physicians and other healthcare providers.
Medical laboratory A medical laboratory or clinical laboratory is a laboratory where tests are carried out on clinical specimens to obtain information about the health of a patient to aid in diagnosis, treatment, and prevention of disease. Clinical Medical laboratories are an example of applied science, as opposed to research laboratories that focus on basic science, such as found in some academic institutions.
Regulation Regulation is the management of complex systems according to a set of rules and trends. In systems theory, these types of rules exist in various fields of biology and society, but the term has slightly different meanings according to context.
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Proprietary software Proprietary software, also known as non-free software or closed-source software, is computer software for which the software's publisher or another person reserves some licensing rights to use, modify, share modifications, or share the software, restricting user freedom with the software they lease. It is the opposite of open-source or free software.
Competitive landscape Competitive landscape is a business analysis method that identifies direct or indirect competitors to help comprehend their mission, vision, core values, niche market, strengths, and weaknesses. Based on the volatile nature of the business world, where companies represent a competition to others, this analysis helps to establish a new mind-set which facilitates the creation of strategic competitiveness.Due to the hypercompetition of the environment, the traditional sources of getting competitive advantage does not represent any more an effective strategy, as a result of the emergence of a global economy and technology.
Form I-140 Form I-140, Immigrant Petition for Alien Worker is a form submitted to the United States Citizenship and Immigration Service (USCIS) by a prospective employer to petition an alien to work in the US on a permanent basis. This is done in the case when the worker is deemed extraordinary in some sense or when qualified workers do not exist in the US. The employer who files is called the petitioner, and the alien employee is called the beneficiary; these two can coincide in the case of a self-petitioner.
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Oracle Database Oracle Database (commonly referred to as Oracle DBMS, Oracle Autonomous Database, or simply as Oracle) is a multi-model database management system produced and marketed by Oracle Corporation.\nIt is a database commonly used for running online transaction processing (OLTP), data warehousing (DW) and mixed (OLTP & DW) database workloads.
FTC v. Actavis, Inc. FTC v. Actavis, Inc., 570 U.S. 136 (2013), was a United States Supreme Court decision in which the Court held that the FTC could make an antitrust challenge under the rule of reason against a so-called pay-for-delay agreement, also referred to as a reverse payment patent settlement.
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National Register of Historic Places The National Register of Historic Places (NRHP) is the United States federal government's official list of districts, sites, buildings, structures and objects deemed worthy of preservation for their historical significance. A property listed in the National Register, or located within a National Register Historic District, may qualify for tax incentives derived from the total value of expenses incurred in preserving the property.
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List of equipment of the People's Liberation Army Ground Force This is a list of military equipment in service with the People's Liberation Army Ground Force, either presently, or former equipment that has since been replaced.\n\n\n== Individual equipment ==\n\n\n== Small arms and light weapon ==\n\n\n=== Small arms ===\n\n\n=== Grenades, explosives, and missiles ===\n\n\n=== Mortars and recoilless rifles ===\n\n\n=== Other ===\n\n\t\t\n\t\t\n\t\t\n\t\t\n\n\n== Artillery ==\n\n\n=== Gun artillery ===\n\n\n=== Multiple rocket artillery ===\n\n\n=== Anti-aircraft artillery ===\n\n\n=== Other ===\n\n\t\t\n\t\t\n\t\t\n\t\t\n\n\n== Vehicle ==\n\n\n=== Armored combat vehicles ===\n\n\n=== Anti-tank/anti-structure vehicles ===\n\n\n=== Logistic and support vehicles ===\n\n\n=== Other ===\n\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\n\n== Vessel ==\n\n\n== Aircraft ==\n\n\n== Equipment summary (2021) ==\nData estimated by The International Institute for Strategic Studies.
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Risk Factors
QLT INC/BC Item 1A RISK FACTORS In addition to the other information included in this Annual Report, you should consider carefully the following factors, which describe the risks, uncertainties and other factors that may materially and adversely affect our business, products, financial condition and operating results
We are identifying these as important factors that could cause actual events or our actual results to differ materially from those contained in any written or oral forward-looking statements (within the meaning of the Private Securities Reform Act of 1995 and “forward looking information” within the meaning of Canadian securities legislation) made by us or on our behalf in this Annual Report or elsewhere
The risks described below are not the only ones that may exist
Additional risks not currently known by us or that we consider immaterial at the present time may also impair our business operations and financial condition
We are relying upon the safe harbor for forward-looking statements and information and any such statements are qualified by reference to the cautionary statements set out elsewhere in this Annual Report
Risks Relating to Our Business We face new competition for Visudyne
We may not be successful in addressing competition for Visudyne, Eligard or our other products
We may be unable to contend successfully with current or future competitors
The pharmaceutical and biotechnology industries are characterized by rapidly evolving technology and intense competition
Our competitors include major pharmaceutical and biopharmaceutical companies, many of which have access to financial, technical and marketing resources significantly greater than ours and substantially greater experience in developing and manufacturing products, conducting preclinical and clinical testing and obtaining regulatory approvals
We are aware of a number of competitors and potential competitors to our products and the impact on the sales of our products and our revenue from the sales of our products may be material
Some of these competitors are also our collaborators
For example, Novartis Ophthalmics, who has the marketing rights to our product Visudyne, has also acquired rights to market Lucentis outside of North America, a product that when approved will be competitive with Visudyne
The following are examples of competitors to certain of our approved proprietary products: Visudyne Competition — There are a number of competitive products to Visudyne that are approved, pending approval or in development
These competitors include: Genentech and Novartis Ophthalmic’s Lucentis™ which is currently pending regulatory approval in the US and Europe, Genentech’s Avastin^® which is approved for cancer but is being used off-label extensively by physicians for the treatment of wet AMD, Eyetech (now part of OSI Pharmaceuticals, Inc
) and Pfizer’s Macugen^® which is approved in the US and Europe for the treatment of all 31 _________________________________________________________________ forms of wet AMD, and Alcon’s Retaane^® which is the subject of an approvable letter in the US (which we expect means that Alcon may need to conduct further studies prior to obtaining registration in the US) and is approved in Australia
are also developing or may develop competitive therapies targeted for wet AMD employing different technologies
We also believe that Visudyne could be competing against surgical or other treatments for AMD, including macular translocation, submacular surgery and laser photocoagulation, among others
Eligard Competition — There are a number of approved products on the market with which our Eligard products compete
These include AstraZeneca’s Zoladex^® product, Bayer Pharmaceuticals Corporation’s Viadur^® product, Watson Pharmaceuticals, Inc
Aczone Competition — Upon commercialization, our Aczone product will directly compete against several other prescription topical products for the treatment of acne
These include, but are not limited to, erythromycin/benzoyl peroxide, clindamycin/benzoyl peroxide, tretinoin, and adapalene products
Aczone will also compete indirectly with systemic prescription products and topical over-the-counter therapies
In addition, we face competition on all of our generic dermatology products, although none of the generic dermatology products are individually material to our business
We are aware of other products manufactured or under development by competitors that are used for the prevention and treatment of certain diseases that we have targeted for product development
The existence of these products, or other products or treatments of which we are not aware, or products or treatments that may be developed in the future, may adversely affect the marketability of our products
More information on the competitors and potential competitors can be found under Item 1
Business-Competition
If there is an adverse outcome in the ongoing patent litigation with TAP Pharmaceuticals, Inc
or any other litigation or other legal actions in which we are or may become involved our business may be harmed
We and certain of our subsidiaries are or may become involved in various types of litigation that arise from time to time in the ordinary course of our business
We are currently a defendant in four lawsuits filed against us
In one lawsuit which was commenced in the US by TAP Pharmaceuticals, Inc
and its co-plantiffs, we recently lost the trial court decision and intend to appeal this decision
The US TAP litigation began in 2003 when TAP and its co-plaintiffs sued Atrix Laboratories, Inc
(now our subsidiary, QLT USA) and Sanofi-Synthelabo alleging that QLT USA’s Eligard product infringes their ‘721 patent, which expires on May 1, 2006
In the TAP litigation, a jury upheld the validity of the ‘721 patent and the US District Court for the Northern District of Illinois Eastern Division denied defendants’ defense that the ‘721 patent is unenforceable due to inequitable conduct by the patentees before the US Patent and Trademark Office
The discovery and pre-trial phase for the damages portion of the trial is scheduled to begin in 2006
QLT USA and Sanofi-Synthelabo intend to appeal the adverse judgment to the Court of Appeals
Under the marketing agreement entered into between QLT USA and Sanofi-Synthelabo under which Sanofi-Synthelabo commercializes our Eligard products in the US and Canada, QLT USA has provided certain indemnities to Sanofi-Synthelabo and its affiliates, including indemnities covering certain losses relating to infringement of a third party’s patent rights
While we cannot currently estimate the potential damages in the TAP litigation in the event that QLT USA is unsuccessful in its appeal, or what level of indemnification, if any, will be required under the marketing agreement with Sanofi-Synthelabo, the amount could be substantial, which could have a material adverse impact on the financial condition of QLT USA and consequently, on QLT Inc
Litigation is inherently unpredictable, and excessive verdicts do occur which may include a judgment with significant monetary award, including the possibility of punitive damages, a judgment that certain of our patent or other intellectual property rights are invalid or unenforceable and, as has occurred in the US litigation with TAP Pharmaceuticals, the risk that an injunction could be issued preventing the manufacture, marketing and sale of our products that are the subject of the litigation
Furthermore, we will have to incur substantial expense in defending these lawsuits and the time demands of these lawsuits could divert management’s attention from ongoing business concerns and interfere with our normal operations
Although we believe we have substantial defenses in these matters, we could in the future incur judgments or enter into settlements of claims that could have a material adverse effect on our financial condition and results of operations in any particular period
For further details of the 32 _________________________________________________________________ litigation with TAP Pharmaceuticals, Inc
and its co-plaintiffs and the current status of our other intellectual property litigation, please refer